The present study was aimed to elucidate the effect of Nonsteroidal

anti-inflammatory drugs (NSAIDs) induced toxicity in the broiler chicken. For this purpose, 120 broiler chicks were utilized and divided into 4 major groups (C, D, B and N) and within each major group the chicks were divided into 3 sub groups having 10 chicks each. The control chicks received normal diet without any medicine. Diclofenac was used @ 10, 20 and 30 mg/kg b.wt. in D1, D2 and D3 group respectively. Ibuprofen was fed @ 15, 30, 45 mg /kg b.wt in B1, B2 and B3 group respectively. The nimesulide group viz. N1, N2 and N3 were given Nimesulide @ 10, 20 and 30 mg/kg b.wt respectively. NSAIDs induced toxicity showed no effect on the haematological parameters of broiler chicks in the present study, however, there was increase in the serum alkaline phosphatase level in intoxicated birds indicating hepatotoxicity compared to the control group with highest value of 173.33 ± 0.80 IU/L in B3. Further, atrophy of spleen and bursa of fabricius was observed in intoxicated birds. Highest atrophy of spleen (1.1 gm/kg body weight) was observed in N3 and D3 while as maximum bursal atrophy of 1.20 ± 0.06 gm/kg body weight was recorded in B3.